TY - JOUR T1 - Prognostic factors of survival among adult patients admitted in the ICU due to severe H<sub>1</sub>N<sub>1</sub> pneumonia JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p4351 AU - Afroditi Boutou AU - Georgia Pitsiou AU - Paschalina Kontou AU - Kalliopi Chatzika AU - Fotini Abatzidou AU - Ioannis Stanopoulos AU - Ioannis Kioumis Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p4351.abstract N2 - Background: Data on the mortality of H1N1 pneumonia among patients admitted in the Intensive Care Unit (ICU) vary.Aim: To describe the characteristics of the adult patients who were admitted in three ICUs of a major Greek hospital due to H1N1 virus pneumonia and to identify predictors of survival.Methods: 25 patients with H1N1 pneumonia (72% male; 28% female; 49.7±15 years old) who were admitted in the ICU between October 2009 and February 2011, were retsrospectively studied. Severity of disease scores, comorbidities, disease complications, time of diagnosis and treatment effect were recorded. Mann-Whitney test and x2 test were used for statistical comparisons.Results: At ICU admission, APACHE II score and CURB-65 score were 15.8±4.9 and 2.4±0.9 correspondingly, while 40% of patients presented with ≥2 major complications (ARDS, acute renal failure, myocardial ischemia or shock). Obesity, immunocompromise, coronary heart disease and diabetes mellitus were present in 36%, 32%, 24% and 24% of patients correspondingly, while 44% of them were smokers. The detection of pharyngeal smear antigen took place in 5.5±3.7 days, oseltamivir initiation in 6.2±3.9 days and ICU admission in 7.3±6.8 days, since the establishment of the disease. H1N1 infection was fatal for 72% of patients.The improvement of the radiologic pattern after oseltamivir initiation (p&lt;0.001) and the absence of septic shock (p&lt;0.001) were the only factors associated to survival.Conclusions: The mortality of patients admitted in ICU due to H1N1 virus pneumonia was high. Although oseltamivir administration was beneficial in some cases, there was a delay in the diagnosis of the disease and the initiation of treatment. ER -