RT Journal Article
SR Electronic
T1 Effect of whole body periodic acceleration on airway endothelial function in smokers, non-smokers and asthmatics
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p890
VO 38
IS Suppl 55
A1 Jose Cancado
A1 Eliana Mendes
A1 Johana Arana
A1 Patricia Rebolledo
A1 Cameron Dezfulian
A1 Adam Wanner
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p890.abstract
AB Rationale: Cigarette smoking and asthma are associated with attenuated endothelium-dependent vasodilation in the airway. Endothelial shear stress activates endothelial nitric oxide synthase (eNOS), leading to endothelium-dependent vasodilation. It has been shown that whole body periodic acceleration (WBPA), activates eNOS. However, the effect of WBPA on endothelial function in the airway has not been investigated.Objective: To assess the effect of a single WBPA session on beta-2 agonist induced, endothelium-dependent vasodilation (ΔQaw) in 15 current smokers, 15 never-smokers with asthma, and 15 healthy never-smokers, with the expectation that the treatment would transiently improve endothelial function.Methods: ΔQaw was defined as the Qaw response to inhaled albuterol (180μg). Nitrite and S-nitrosothiol blood levels (NO) were assayed using a tri-iodide based reductive chemiluminescence method. All measurements were made before and immediately after a 45 minutes WBPA treatment using Exer-Rest®.Results: WBPA increased mean baseline Qaw by 15.14±3.53 μl/min/ml in non-smokers (p<0.001) but had no effect on Qaw in smokers and asthmatics. ΔQaw remained unchanged in all three groups. NO levels tended to increase in asthmatics (13%) and non-smokers (31%), but the changes did not reach statistical significance.Conclusions: A single session of WBPA increases airway blood flow in healthy non-smokers, but not in smokers and asthmatics. The treatment has no effect on the blunted endothelium-dependent vasodilation in smokers and asthmatics nor does it augment normal endothelium-dependent vasodilation in healthy non-smokers despite a tendency toward eNOS activation