PT  - JOURNAL ARTICLE
AU  - Takashi Yamane
AU  - Akihito Yokoyama
AU  - Naoki Shiota
AU  - Hiroshi Ohnishi
AU  - Noboru Hattori
AU  - Nobuoki Kohno
TI  - Reduced lung function is an independent risk factor for the development of impaired glucose tolerance?
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p1759
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p1759.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p1759.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Objectives: Whether reduced pulmonary function is a risk factor for the development of impaired glucose tolerance (IGT) has yet to be determined. The aim of the present study is to obtain more information on this point in Japanese males.Methods: First, 975 men showing normal lung function without respiratory disease were recruited in cross-sectional research. All the subjects were divided into quartiles according to baseline%FVC,%FEV1, and FEV1% and analyzed the ratio of IGT and DM. Next, 511 men showing normal pattern in 75g OGTT were recruited in longitudinal research. The subjects were divided into%FVC,%FEV1, and FEV1% quartiles, we compared the cumulative incidence rates of IGT among the four groups, and analyzed the risk factors for the development of IGT.Results: In the cross-sectional research, the rates of IGT and DM for each quartile at first examination were significantly associated with lower%FVC and%FEV1 quartile, but not significantly with lower FEV1% quartile. During the mean follow-up period of 28.4±6.0 months, 89 (17%) among 511 normal glucose tolerance (NGT) subjects developed IGT during this period. The cumulative incident rates of IGT for each quartile were significantly higher in lower%FVC and%FEV1 group, but not significantly with lower FEV1% quartile. In a Cox proportional hazards model, only lower%FVC quartile was an independent risk for development of IGT adjust for age, BMI, systolic BP, total cholesterol, CRP, and pack-year smoking.Conclusions: Not reduced%FEV1 and FEV1% but reduced%FVC is an independent risk factor for the development of IGT in Japanese males.