RT Journal Article
SR Electronic
T1 Comparison of inflammatory response biomarkers to predict complications in hospitalized patients with community-acquired pneumonia
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p1472
VO 38
IS Suppl 55
A1 Ane Uranga
A1 Pedro Pablo España
A1 Alberto Capelastegui
A1 Inmaculada Gorordo
A1 Rosa Diez
A1 Amaia Bilbao
A1 Carmen Mar
A1 Edurne Bereciartua
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p1472.abstract
AB Background: Recently, an extensive research has gone into identifying the predictive value of biomarkers for complications in community-acquired pneumonia (CAP).Objective: The aim of this study was to evaluate the utility of inflammatory biomarkers measured on admission in hospitalized patients with CAP.Methods: We prospectively included patients over 18 years old for a period of one year. Procalcitonin (PCT), C reactive protein (CRP) and Pro adrenomedullin (ProADM) were compared in predicting complications occurred in the follow-up of 30 days. Mortality, severe sepsis, ventilation and/or septic shock and ICU/IRCU admission were the complications analyzed. For the comparison of biomarkers, the nonparametric Wilcoxon test was used, whereas AUC was used to measure the predictive ability of each biomarker.Results: A total of 320 patients with diagnosis of CAP were included in our study and samples for biomarkers could be extracted in 258 of them. Table 1 shows the results of the comparison of the biomarkers according to each outcome, and the AUC values. Biomarkers are described as median and interquartile range.Conclusion: ProADM is a powerful tool for the prediction of mortality and other complications in hospitalized patients with CAP. In addition, we found that PCT has the greatest predictive value for complications such as ventilation/shock or ICU/IRCU admission.