TY - JOUR T1 - RANTES gene promoter polymorphisms -28C/G and -403G/A in children hospitalized with community acquired pneumonia JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p510 AU - Katerina Haidopoulou AU - Theonymfi Doudouliaki AU - Styliani Pappa AU - Afroditi Sakellaropoulou AU - Pavlos Tsakiridis AU - Maria Emporiadou AU - Maria Xatzistylianou Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p510.abstract N2 - The course of community acquired pneumonia in children varies between patients and it is common belief that the innate immune system of the host plays an important role to the outcome of the infection. The chemokine RANTES is an important chemoattractant which attracts monocytes, T cells, NK cells and eosinophils into sites of inflammation.Aim of the study was to investigate the frequency of -28C/G and -403G/A RANTES polymorphisms in children hospitalized with community-acquired pneumonia.The study involved two groups of children. The first (group A) consisted of 60 children hospitalised with pneumonia, 37 boys, aged 5±0,44 years and the second (group B) consisted of 135 healthy children, 60 boys, aged 9,6±0,2 years with no history of respiratory infections.The genotypes of all subjects were determined with PCR-RFLP assay.View this table:Frequency of genotypes and alleles of RANTES –28 C/G and –403 G/A promoter polymorphismsAccording to the results, only the -28C/G RANTES promoter polymorphism is associated with community-acquired pneumonia in children. No association was found for the -403G/A polymorphism. ER -