PT - JOURNAL ARTICLE AU - Cebrail Simsek AU - Özlem Sönmez AU - Ahmet Yurdakul AU - Füsun Özmen AU - Nurullah Zengin AU - Atilla Keyf AU - Dilek Kubilay AU - Özlem Gülbahar AU - Senem Karatayli AU - Mithat Bozdayi AU - Can Öztürk TI - Diagnostic accuracy of SELDI-TOF-MS (surface enhanced laser desabsorbtion ionization time of flight mass spectrometry) method in early diagnosis of lung cancer DP - 2011 Sep 01 TA - European Respiratory Journal PG - 4501 VI - 38 IP - Suppl 55 4099 - http://erj.ersjournals.com/content/38/Suppl_55/4501.short 4100 - http://erj.ersjournals.com/content/38/Suppl_55/4501.full SO - Eur Respir J2011 Sep 01; 38 AB - Objective: Early diagnosis of lung cancer is critical for successful treatment and improving the outcome of patients. The cancer cells synthesize proteins as well as all of the other cells. Cancer may be recognised with these proteins profiles analysed with any methods. With SELDI-TOF-MS method, protein profiles can be obtained from serum, pleural fluid, urine and tissue samples.The goal of this study was to identified protein profiles and to distinguish lung cancer patients from healty individuals by serum protein profiles.Methods: 170 patients with lung cancer, 53 individuals with no evidence lung cancer but high risk for lung cancer and 47 healthy individuals totally 270 individuals were included in this study.Venous samples were taken from all cases. All of the serum samples were analyzed by SELDI-TOF-MS method for proteomics investigation.Results: SELDI-TOF spectra of patients with lung cancer, healthy control and high risk are shown for the most discriminatory peaks of 11480 m/z, 11547 m/z and 11679 m/z.View this table:Discriminatory proteomic features between lung cancers and healthy controlsThese proteomic features were present in only lung cancer group, but not in healthy control or high risk groups.Conclusion: SELDI-TOF-MS method can correctly distinguish patients with lung cancer from healthy individuals and SELDI-TOF-MS method may be a new tool in diagnosis and screening test for lung cancer.