TY - JOUR T1 - Comparison between SCOT-15® and Perfadex® as lung preservation solutions JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - 222 AU - Anne Olland AU - Caroline Meers AU - Malika Benahmed AU - Karima Elbayed AU - Shana Wauters AU - Eric Verbeken AU - Geert Verleden AU - Izzie Namer AU - Dirk Van Raemdonck Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/222.abstract N2 - Objectives: SCOT-15® is a low K+ solution including polyethyleneglycol (PEG) as a colloid for protection of endothelium. PEG was demonstrated to have immunocamouflage properties and has been tested for kidney, pancreas and liver preservation. This study compares the properties of SCOT-15® for lung preservation with Perfadex® as a golden standard.Methods: Two groups of 6 pigs each were compared. After 2L cold pulmoplegia with either Perfadex® [P] or SCOT-15® [S], lungs were stored cold for 4 hours. Peripheral lung biopsies were taken for High Resolution Magic Angle Spinning (HRMAS) detection of colloids. Lung function was assessed in an ex vivo lung perfusion and ventilation model. Pulmonary artery flow and pressure were recorded for pulmonary vascular resistance (PVR), mean airway pressure (mAwP) for lung compliance and blood gases on the perfusion outflow line for partial oxygen pressure (PO2). Wet-to-dry weight ratio (W/D) was recorded for edema.Results: PVR was significantly lower in [S] compared to [P] (p=0.04). There were no differences in PO2 (p=0.13), mAwP (p=0.24) and W/D (p=0.06). HRMAS spectra showed presence of PEG in peripheral lung tissue in [S].Conclusion: Lungs preserved with SCOT-15® had lower vascular resistance with comparable oxygenation capacity reflecting well preserved endothelial function. Experiments with longer cold ischemia are needed to assess the relevance of this solution. ER -