RT Journal Article
SR Electronic
T1 Pulmonary toxicity in car spray painters
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p4943
VO 38
IS Suppl 55
A1 Ibrahim Ibrahim
A1 Ahmad El-Ebiary
A1 Arwa Abuelfadl
A1 Enas El-Maddah
A1 Safinaz El-Shourbagy
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p4943.abstract
AB Background: Spray painters comprise a large population at risk with potentially high isocyanate exposure. Repeated pulmonary function testing is not sufficient to diagnose and evaluate pulmonary toxicity induced by car paint sprays. Therefore Clara cell secretory protein (CC16) was selected as a sensitive marker of bronchial tree injury.Methods: The study involved 50 workers exposed to isocyanates during car spray-painting; in addition to 30 control subjects,. All participants were subjected to pulmonary function testing, bronchoscopy and lavage, and serum CC16 estimation.Results: Different pulmonary function indices as well as CC16 serum levels were found to be significantly decreased in the exposed group. Clara cells were markedly damaged in the exposed subjects, whereas smokers exhibit excessive epithelial cells desquamation.View this table:Serum levels of CC16 (ng/ml) in exposed and control subjectsConclusions: In this study clear associations between lung function parameters, CC16 serum levels, and exposure to isocyanate-containing paint-sprays were demonstrated. This stresses the importance of regulation and control of such exposure. Also, assay of serum CC16 could be used to detect pulmonary toxic effects.