PT  - JOURNAL ARTICLE
AU  - Asunciόn Nieto, M.
AU  - Morales, Beatriz
AU  - Feranadez-Golfín, Covadonga
AU  - Benedetti, Paola
AU  - Rodriguez-Trigo, Gema
AU  - Gerasimova, Ina
AU  - Άlvarez-Sala Walther, José Luis
TI  - Combined pulmonary fibrosis and emphysema. Descriptive analysis from a specialized clinic of interstitial lung disease
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p3746
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p3746.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p3746.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - The combination of pulmonary fibrosis and emphysema (CPFE) is a recently defined syndrome characterized with pulmonary fibrosis (PF) and emphysema.Aim: To analyze the clinical, functional, radiological and echocardiographic features in patients with CPFE.Method: Prospective study conducted in a specialized clinic of ILD from 01/01/2007 to 31/12/2010. PF was defined as reticular opacities with peripheral and basal predominance, honeycombing, architectural distortion and/or traction bronchiectasis without ground glass opacities in HRTC and emphysema as the presence of areas of low attenuation with a very thin or no wall and/or bullaes with upper zone predominance.Results: We anlized 20 patients, 90% men; mean age 74 years; 91% were smokers or ex-smokers, 60% had dyspnoea, 75% basal crackles and 25% finger clubbing. The pulmonary function tests are shown in table 1. Pulmonary hypertension was detected in 5 of 10 patients who underwent echocardiography.View this table:Pulmonary function tests in 20 patientsConclusions: The finding of lung volumes normal o minimally altered in contrast to a severe reduction in TLCO and arterial hypoxemia should alert to the possibility of CPFE. The prevalence of PH in these patients is high.