RT Journal Article
SR Electronic
T1 Can flaxseed oil reduce experimental lung fibrosis in rats?
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p672
VO 38
IS Suppl 55
A1 Anouar Abidi
A1 Raja Srairi
A1 Nadia Kourda
A1 Fatma Tritar
A1 Sonia Maalej
A1 Leila Douik
A1 Moncef Fekih
A1 Saloua Ben Khamsa
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p672.abstract
AB Background: The anti-inflammatory effects of poylunsaturated fatty acids (PUFA) is actually demonstrated. In this study we evaluated protective and therapeutic effects of Flaxeeed Oil (FO) on Bleomycin (BLM) lung fibrosis in rats.Methods: 30 males wistar rats were randomly divided into 3 equal groups: untreated group (G1) and 2 treated groups (FO, 1g/kg bw/day). G2 received FO during two months before inducing lung fibrosis than G3 received FO 2 days after inducing lung fibrosis during 10 days. Pulmonary fibrosis was induced by BLM (4 mg/kg, intratracheally single dose). Inflammatory index, fibrosis score (Ashcroft) and TGF-β density was evaluated in different areas of damaged lung by anatomo-histological and immuno-histological analysis.Results: Independent-samplesTtest revealed that comparatively to control group (G1). FO reduced significantly fibrosis score in G2 and TGF-β density in fibrocytes in G3 (p<0,05).Figure 1. Distribution of TGF-β in fibrocytes of treated groups (G2, G3) and control group (G1).Figure 2. Score of fibrosis of treated groups (G2, G3) and control group (G1).Conclusion: These data demonstrated a protective activity of FO against bleomycin-induced lung fibrosis model in rats.More investigations will be realized in human to prove relationship between diet and interstitial lung diseases.