RT Journal Article
SR Electronic
T1 Role of systemic and bronchial oxidative stress and inflammation in lung cancer predisposition in patients with COPD
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p2786
VO 38
IS Suppl 55
A1 Clara Fermoselle
A1 Victor Curull
A1 Albert Sanchez-Font
A1 Lara Pijuan
A1 Joaquim Gea
A1 Esther Barreiro
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p2786.abstract
AB Chronic airway inflammation such as that observed in COPD patients is a relevant contributor to lung cancer. Increased inflammation and oxidative stress levels have been shown in lung cancer lesions compared to non-tumor parenchyma.Objectives: Levels of inflammation, redox balance, and angiogenesis were determined in the airways and blood of out-patients with lung cancer with and without COPD.Methods: Oxidative stress, inflammation, angiogenesis, and growth factor levels were quantified (immunoblotting, ELISA, activity assays, and chemiluminescence) in the airways (bronchoscopy) and blood of: 1) patients with COPD and lung cancer (n=39), 2) patients with lung cancer without COPD (n=14), 3) patients with COPD without lung cancer (n=9), and 4) healthy subjects with no lung disease (n=12).Results: In patients with COPD and lung cancer, blood superoxide anion, systemic oxidized DNA and proteins, and bronchial protein oxidation were increased compared to healthy controls. In patients with lung cancer, only protein oxidation was greater in their bronchi than in healthy controls. Antioxidant enzyme activity did not differ among groups in either blood or bronchi. TNF-alpha, interferon-gamma, and VEGF levels were higher in the blood and bronchi of patients with COPD and lung cancer and lung cancer only than in healthy controls.Conclusions: While COPD induces an increase in systemic and bronchial oxidative stress in patients with associated lung cancer, the latter condition is related to greater content of proinflammatory cytokines and angiogenic factors in both blood and bronchi of the patients.Funded by: SEPAR 2007, SOCAP 2007, MTV3-07-1010, 2009-SGR-393, & CIBERES.