PT  - JOURNAL ARTICLE
AU  - Thanasekaraan, Vijayalakshmi
AU  - Duvuru, Prathiba
AU  - Rao, Shalinee
AU  - Mohamed, Safreena
AU  - Sundar, Samuel John
TI  - An analysis of EGFR expression and tumour imaging in non-small cell carcinomas of lung
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p2747
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p2747.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p2747.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Introduction: Non-small cell carcinomas (NSLC) accounts for 80% of all lung cancers. Epidermal growth factor receptor (EGFR) is frequently overexpressed in NSLC and it plays a significant role in tumour cell proliferation and progression. The correlation of EGFR expression with radiological features may reveal their possible relationship.Aim: To evaluate EGFR expression in NSLC and correlate with their radiological features.Material and method: Twenty -two cases of NSLC were histologically subcategorized based on WHO classification of lung carcinomas. Immunostaining for TTF-1, p63 and EGFR were performed on paraffin embedded tissue sections and their expression evaluated. Chest tomography was reviewed to assess for tumour location, diameter, contours, margins, cavitation and lymph node enlargement. Findings of radio-imaging and EGFR immunoexpression were correlated.Results: Fourteen cases of adenocarcinoma and 8 cases of squamous cell carcinoma were identified. Epidermal growth factor receptor expression was noted in 86.3% of tumours. About 92.8% of adenocarcinomas and 75% of squamous cell carcinomas were EGFR positive. On radiology, mean diameter of lesion was found to be 36.4mm and 6.1mm in EGFR positive and negative tumours respectively. Fourteen EGFR positive cases were well defined and five poorly defined. Each of all the eight cases with pleural effusion and regional lymphadenopathy were EGFR positive.Conclusion: Major percentage of NSLC showed EGFR expression reinforcing its utility for targeted therapy. A positive EGFR correlation was noted with tumour size, regional lymphnode enlargement and pleural effusion which reflect biologically aggressive property of EGFR positive tumours.