RT Journal Article
SR Electronic
T1 Pediatric pulmonary function testing in infants and toddlers with perinatal burden
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p1120
VO 38
IS Suppl 55
A1 Sulc, Jan
A1 Kredba, Vaclav
A1 Zikan, Jan
A1 Kotatko, Petr
A1 Tukova, Jana
A1 Pohunek, Petr
A1 Kolar, Pavel
A1 Markova, Daniela
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p1120.abstract
AB Methods of infant pulmonary function testing (IPFT) represent an important diagnostic tool for an assessment of chronic lung disease in infancy (CLDI). We assessed lung function in a cohort of children with a perinatal burden.We tested 74 infants and toddlers (birth weight 1.47±1.11kg [mean±SD]; body length at birth 30.8±16.3cm with CLDI. Age at testing was 1.38±0.69 (median 1.35) yrs; body weight 9.0±2.2kg, body length 76.0±9.7cm. The whole-body plethysmography (to measure FRCp and sReff), tidal breathing analysis (tPTEF%tE), baby resistance/compliance (specific Crs) and rapid thoraco-abdominal compression method (VmaxFRC) were performed. MS Baby Body, VIASYS, USA was used. Standard protocols [1] and proper reference values [2] were used.FRCp equals 115.3±41.2% pred (P<0.02), sReff reached 134.6±93.8% pred (P<0.005). A parameter of tPTEF%tE mildly decreased (23.5±10.6%). Specific compliance rs (Crs/kg) was 14.4±3.9 ml/kPa/kg; V'maxFRC reached 136±69 ml/sec.In infants and toddlers with a perinatal burden peripheral and central airway obstruction with mild (secondary) hyperinflation was found. Mildly increased specific compliance of the respiratory system was also found. No restrictive pattern was detected. Serial IPFT assessments in our cohort is required to validate present data.References:1. Hammer J, Eber E (eds). Pediatric Pulmonary Function Testing, 2005, Basel, Karger.2. Hulskamp G et al: Am J Respir Crit Care Med 2003;168:1003-9.Supported by the project “Follow-up of children with perinatal burden” of EEA and Norway grants and by the grant NT/11444-5.