RT Journal Article
SR Electronic
T1 Associations of efficacy outcomes following bronchoscopic thermal vapor ablation (BTVA) for the treatment of heterogeneous emphysema
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p3531
VO 38
IS Suppl 55
A1 Hopkins, Peter
A1 Herth, Felix J.F.
A1 Snell, Gregory
A1 Baker, Kim
A1 Witt, Christian
A1 Gotfried, Mark H.
A1 Valipour, Arschang
A1 Wagner, Manfred
A1 Stanzel, Franz
A1 Egan, Jim
A1 Kesten, Steven
A1 Ernst, Armin
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p3531.abstract
AB Background: The associations among various COPD efficacy endpoints are variable; however, the degree of correlation is often important in examining the consistency of the results across measures that are not considered redundant.Objectives: Determine the correlations of improvements in lung function and CT analysis of lobar volume reduction (LoVR) to health outcomes following treatment of heterogeneous emphysema with BTVA.Methods: Single-arm trial of BTVA in patients with upper lobe predominant emphysema. Patient criteria: FEV1 15% - 45% predicted, age 40-75 years, RV>150%, TLC>100%, 6 minute walk distance (6MWD)>140 m, DLCO>20%, previous pulmonary rehabilitation. Primary efficacy endpoints: FEV1 and St. George's Respiratory Questionnaire total score (SGRQ) at 6 months. Other endpoints: body plethysmography, mMRC dyspnea, 6MWD. Pearson correlation coefficients were calculated for the association of changes from baseline to 6 months of physiologic measures and LoVR to health outcomes.Results: 44 patients received BTVA. Mean age: 63 years, men 50%, FEV1 0.86 (31% predicted), RV 237% predicted, DLCO 35% predicted, SGRQ 59 units, 6MWD 300 m, mMRC 2.9.View this table:Conclusion: Physiologic and CT LoVR outcomes correlate strongest with the BODE score and the perception of dyspnea. The variable degree of correlation among the health outcomes indicates the need to examine multiple efficacy variables in emphysema and reinforce that the measures are not redundant.