RT Journal Article SR Electronic T1 Functional state of endothelium in bronchial asthma children JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP p1144 VO 38 IS Suppl 55 A1 Natalya Orlova A1 Esfir Atkina A1 Larisa Guryeva A1 Lubov Babenkova A1 Gulnara Sakaeva A1 Alfia Biktasheva A1 Svetlana Levasheva YR 2011 UL http://erj.ersjournals.com/content/38/Suppl_55/p1144.abstract AB To examine the association between the functional state of endothelium and bronchial asthma the oxide nitrogen (NO) condition in blood samples was evaluated in 118 bronchial asthma children with a wide range of desease severity with the use of Yemchenko L.N. method (1994) by determination of terminal stabile metabolites, and endothelin-1 (ET-1) concentration with enzyme immunoassays analysis, and also with the use of J. Hladovec method (1978) of circulation endothelial cells (CEC) level establishing. The credible increase of ET-1 (0,525±0,06 fmol/ml), NO (66,59±4,45 mkM/ml), CEC (7,28±0,63 cells/100 mkl) levels in bronchial asthma children compared with control (0,22±0,01 fmol/ml, 29,86±0,77 mkM/ml, 3,03±0,22 accordingly, p<0,01). The levels of endothelial markers credibly decreased on the background of anti-inflammatory therapy by inhalative glucocorticosteroids (NO 82,69±14,38 mkM/ml and 42,12±9,66 mkM/ml, p=0,001; ET-1 0,64±0,15 fmol/ml and 0,35±0,06 fmol/ml, p=0,001; CEC 7,3±1,67 and 5,0±0,32 cells/100 mkl p=0,0017). All the trial results may be used as an additional standard definition of bronchial asthma severity and therapeutic efficiency in bronchial asthma children.