PT  - JOURNAL ARTICLE
AU  - Paschalis Steiropoulos
AU  - Evangelia Nena
AU  - Panagiota Zikidou
AU  - Pavlos Zarogoulidis
AU  - Nikolaos Papanas
AU  - Konstantinos Archontogeorgis
AU  - Theodora Gkioka
AU  - Eleni Pitta
AU  - Argyrios Tzouvelekis
AU  - Stavros Anevlavis
AU  - Marios Froudarakis
AU  - Demosthenes Bouros
TI  - Mean platelet volume in obstructive sleep apnea patients. Another link to cardiovascular disease?
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p1741
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p1741.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p1741.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Pobjective and aims: Various studies have examined the association between Obstructive Sleep Apnea (OSA) and cardiovascular risk. Mean Platelet Volume (MPV) has been evaluated as a potential marker of cardiovascular risk in several lines of patients. The aim of this study was to evaluate MPV in relation to OSA severity, as well as to investigate the associations between MPV and anthropometric characteristics and parameters of breathing function during sleep.Materials and methods: This study included 699 subjects with suspected sleep apnea, who were all evaluated by Epworth Sleepiness Scale (ESS), physical examination and polysomnography. According to Apnea-Hypopnea Index (AHI), patients were divided into 4 groups: Group A (n=156) with AHI<5/h; Group B (n=137) AHI: 5-14.9/h; Group C (n=100) AHI: 15-29.9/h and Group D (n=303) AHI ≥30/h. MPV (blood samples anticoagulated with sodium citrate) was measured in two blood cell counters (Sysmex SF-3000 and Sysmex XE 2100).Results: MPV was significantly higher in group D (mean value 11.7±1.2) than in groups A (9.9±1.2), B (9.9±1.6), and C (10.8±1.8) (p <0.001). In all patients, significant correlations were shown between MPV and AHI (p<0.001), average SpO2 (p<0.001), minimum SpO2 (p<0.001), t<90 (p<0.001), Arousal Index (p<0.001) and ESS (p=0.002), while regression analysis revealed no association between MPV and BMI (p=0.855) or age (p=0.774).Conclusions: MPV is higher in patients with severe OSA and is correlated with various indices of breathing function during sleep, suggesting a role in the pathogenesis of cardiovascular risk in OSA patients.