RT Journal Article
SR Electronic
T1 Ghrelin effects on local renin angiotensin from pulmonary vessels
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p3341
VO 38
IS Suppl 55
A1 Irina Luciana Dumitriu
A1 Elena Cojocaru
A1 Luminita Gina Vata
A1 Marcel Costuleanu
A1 Bogdan Gurzu
A1 Simona Mihaela Slatineanu
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p3341.abstract
AB Background: Published data sustain the participation of vascular renin angiotensin system (RAS) on alteration of pulmonary vessels reactivity during the allergic airway inflammation. Ghrelin is a growth hormone-releasing peptide involved in modulation of immune function.Objective: This study aims to investigate the interaction between ghrelin and local RAS from rat pulmonary vessels during ovalbumin – induced allergic airway disease.Methods: The angiotensinogen (AGT) – induced contractions were assessed on isolated pulmonary artery and veins from ovalbumin sensitized rats receiving either saline (OSR) or ghrelin (OSG) by endotracheal instillation. Experiments were performed in the absence or the presence of losartan, D-ALA7, chymostatin and N-nitro-L-arginine methyl ester (L-NAME).Results: The angiotensinogen (AGT) contractile effects mediated by AT1 receptors were lower with at least 25% on vessels from OSG than from OSR. The D-ALA7 and LNAME significantly increases the AGT - induced contraction on OSG. The amount of nitric oxide released after stimulation with angiotensinogen (AGT) is higher on OSG and it is blocked by D-ALA7.Conclusion: Our results suggested that pulmonary delivery of ghrelin could modulate the local RAS from pulmonary vessels, probably by promoting the angiotensin 1-7 mediated effects. These data sustained the existence of another possible way for ghrelin's beneficial effects on the lung.