PT  - JOURNAL ARTICLE
AU  - Sato, Yoko
AU  - Asakura, Takuma
AU  - Saeki, Noriyuki
AU  - Aoshiba, Kazutetsu
AU  - Kotani, Toru
TI  - Biphasic cuirass ventilation decreased the indices of pulmonary circulation in patients with secondary pulmonary hypertension
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p2288
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p2288.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p2288.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Introduction: Biphasic cuirass ventilation (BCV) is a non-invasive extrathoracic positive/negative pressure mechanical ventilation. We reported BCV decreased pulmonary artery pressure (PAP) in patients with secondary pulmonary hypertension (PH) due to chronic respiratory failure (CRF). In this study, we investigated the effect of BCV on pulmonary circulation to seek the mechanism of decreasing PAP.Methods: Fifteen steady-state PH caused by CRF patients were included. None were given vasodilator and nor diagnosed dehydration. PH was defined as mean PAP (mPAP) >20mmHg determined by right heart catheterization (RHC). Control mode was applied in combination with negative/positive pressure between -15 and - 25cmH2O/3 and 10cmH2O. BCV was performed 1 hour/day for 2 week not to exhaust the patients. Data from RHC, the serum levels of N-terminal proB-type natriuretic peptide (NT-proBNP) and noradrenalin were obtained before and after the trial of BCV. Patients were interviewed the comfort around BCV. Data were analyzed by the Wilcoxon test p<0.05 was considered statistically significant.Results: mPAP, pulmonary artery occlusion pressure and cardiac index decreased significantly (27.3 to 23.1 mmHg, p=0.004, 13.9 to 9.4 mmHg, p=0.018, and 2.72 to 2.44 l/min/m2, P=0.035, respectively) without the increase in pulmonary vascular resistance index. NT-proBNP significantly decreased (240.6 to 110.4 pg/ml, p=0.025, respectively), but noradrenalin didn't change. Eleven patients (73%) answered comfortable during and after BCV.Conclusions: The results suggest BCV decreases cardiac load in these patients. Further studies are needed to assess the clinical and physiological effects of BCV.