RT Journal Article
SR Electronic
T1 Risk factors for recurrent wheezing following bronchiolitis: 3 yrs of follow-up
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p1167
VO 38
IS Suppl 55
A1 Giulia Cangiano
A1 Alessandra Pierangeli
A1 Carolina Scagnolari
A1 Enea Bonci
A1 Corrado Moretti
A1 Paola Papoff
A1 Jole Rabasco
A1 Ilaria Caiazzo
A1 Marianna Ferrara
A1 Stefano Luciani
A1 Fabio Midulla
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p1167.abstract
AB We have previously demonstrated the association between bronchiolitis from Rhinovirus (RV) and recurrent wheezing after one yr of follow-up (Eur Respir J 2010; 36 (54) P2707). Our objective was to identify wheezing recurrence and related risk factors in infants with bronchiolitis from Respiratory Syncytial Virus (RSV), RV, Bocavirus (hBoV), Influenza A and B, Parainfluenza 1-3, Metapneumovirus, Adenovirus and Coronavirus detected from nasal washes with RT-PCR. 208 infants (mean age ± SD 2.4±2.1, range 0.07-11 months, 89 males) hospitalized with bronchiolitis were evaluated for recurrent wheezing (RW) during 3 yrs of follow-up. Demographic and clinical data were obtained from parents with a structured questionnaire and patient's medical files. Of they 208 infants, 152 (73%) answered to the phone call. 104 viruses were identified from 92 infants: RSV in 68 (73.9%), RV in 15 (16.3%), hBoV in 17 (18.5%), RSV+hBoV in 10 (10.9%), other viruses in 4 (4.34%). 34.9% of the infants with bronchiolitis had RW at the 3rd yr of follow-up. The related risk factors for RW were blood eosinophils counts > 400 cells/mm3 (OR 9.26; CI 95% 1.09,79.0), breast feeding more than 2 months (OR 2.43; CI 1.20,4.89) and bronchiolitis from RV (OR 3.17; CI 1.03,9.79). At the 3rd yr of follow-up, 66.7% of the infants with bronchiolitis from RV have RW comparing to 57.1% of the infants with bronchiolitis from hBoV, 39.7% of the infants with bronchiolitis from RSV, 30% of the infants with bronchiolitis from RSV+hBoV and 25% of the infants with bronchiolitis from other viruses. In conclusion infants with RW at the 3rd yr of follow-up after acute bronchiolitis seem to be those with atopic predisposition and a specific viral infection.