RT Journal Article
SR Electronic
T1 The comparison of the findings of preoperative PET-CT and surgical pathology in patients with non-small cell lung cancer those with and without induction therapy
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p4330
VO 38
IS Suppl 55
A1 Ahmet Üçvet
A1 Soner Gürsoy
A1 Ahmet Erbaycu
A1 Seyda OKaya
A1 Hakan Koparal
A1 Zekiye ADinc
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p4330.abstract
AB PET-CT has been widely used to evaluate the response to induction therapy in lung cancer. We aimed to reveal the accuracy of PET-CT in defining the pathological response to chemotherapy/radiotherapy and compare with patients operated without induction therapy in non-small cell lung carcinoma (NSCLC).Patients, performed lung and mediastinal lymph node dissection for NSCLC, after a staging procedure with PET/CT, were included. In first group, patients had had induction therapy for a stage IIIA and IIIB disease, before PET-CT. In the second, patients had surgical resection after PET-CT evaluation. The postoperative histopathological and preoperative PET-CT findings were compared.There were 58 patients in group 1 and 159 patients in group 2. The sensitivity, positive predictive value (PPV) and accuracy of PET-CT for primary tumor were 92%, 92%, 86% in group 1 and 99%, 100%, 99% in group 2. In group 1, the specifity and negative predictive value (NPV) were 50% and 50%. For N2 disease; the sensitivity, specifity, PPV, NPV and accuracy were 44%, 88%, 58%, 80%, 76% in group 1 and 43%, 89%, 16%, 97%, 87% in group 2. The sensitivity, PPV and accuracy of primary tumor and NPV and accuracy of N2 disease were significantly lower at group 1.In patients with NSCLC those had had induction therapy, the negativity of PET-CT should be examined better than the patients those had not had preoperative therapy and it should not be avoided to perform invasive staging procedures. The positivity of lymph nodes in PET-CT should be confirmed by histopathology. When PET-CT findings after induction therapy is used, NPV and accuracy is lower.