RT Journal Article
SR Electronic
T1 Longitudinal assessment of lung function in children and adolescents with sickle cell anaemia
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p1119
VO 38
IS Suppl 55
A1 Lunt, Alan
A1 Rafferty, Gerrard F.
A1 Rees, David
A1 Height, Sue
A1 Greenough, Anne
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p1119.abstract
AB Aim: Lung function studies in children with sickle cell disease (SCD) have not identified consistent abnormalities. The results, however, of two cross-sectional studies suggest restrictive abnormalities become more prominent with increasing age. Our aim was, by undertaking serial comprehensive assessments in SCD children, to further characterize any changes in lung function with increasing age.Methods: Two cohorts of SCD children were recruited. Cohort 1: 21 children, mean age at baseline 8.1 (range 2.9-12.0) years and mean length of follow-up 1.9 (1.7-2.1) years. Cohort 2: 28 children and adolescents, mean age at baseline 10.0 (6.0-15.5) years and mean length follow-up 9.0 (8.1-9.8) years. Lung function was assessed by spirometry and body plethysmography.Results: Lung function declined significantly in both cohorts. The results are expressed as median (IQR) and percentage predicted for height.View this table:Table 1. Lung function at baseline and follow-up for cohort 1View this table:Table 2. Lung function at baseline and follow-up for cohort 2Comparison of the data from the two cohorts demonstrates a faster decline in cohort one.Conclusion: Children and adolescents with SCD suffer deterioration in lung function with increasing age; the speed of decline is greatest in young children.