RT Journal Article
SR Electronic
T1 Can asthma control test (ACT) replace a global assessment of asthma control according to GINA guidelines?
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p3512
VO 38
IS Suppl 55
A1 Lorenza Melosini
A1 Federico Lorenzo Dente
A1 Elena Bacci
A1 Maria Laura Bartoli
A1 Antonella Di Franco
A1 Federica Novelli
A1 Manuela Latorre
A1 Vagaggini Barbara
A1 Paggiaro Pierluigi
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p3512.abstract
AB Background: Asthma Control test (ACT) has been proposed as a surrogate of the assessment of asthma control, but there is controversy if it corresponds to GINA criteria (O'Byrne, ERJ 2010).Aim: To compare GINA assessment of asthma control and ACT scorePatients and methods: We evaluate 68 outpatients (33 in inhaled corticoseroids, ICS, treatment, and 35 ICS-naïve), with mild-to-moderate asthma. Assessment of asthma was based on symptom score (SS), rescue salbutamol (RS), PEF (MA%), pulmonary function, and asthma exacerbations in the last year (GINA guidelines).Results: ACT score significantly correlated with SS (r= 0.49), RS (r= 0.46) and MA% (r= 0.45), not with FEV1. ACT score only partially correlated with GINA categories of well (WC), partly (PC) and uncontrolled (UC) patients.View this table:Contingency table between asthma control level (according to GINA Guidelines, gold standard) and ACT categoriesACT ≥ 20 had high Positive Predictive Value for WC+PC (PPV: 78%), while ACT ≤ 19 had high Negative Predictive Value for UC (NPV: 89%).Conclusion: Cut-of value of ACT has a good accuracy for detecting uncontrolled asthmatics, but not for distinguish well from partly controlled asthmatics. The high correlations with data derived from 2-week diary card recording support ACT as a simple tool for the quantification of symptomatic asthma control.