TY - JOUR T1 - Is radiologic evidence of interstitial infiltrate enough to predict FEV1 and DLCO disparity in lung cancer patients? JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p2757 AU - Frederico Fernandes AU - Gustavo Prado AU - Juliana Puka AU - Salge João Marcos AU - André Albuquerque AU - Mariana Araujo AU - Paula Chaves Sampaio AU - Milena Suesada AU - Teresa Takagaki Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p2757.abstract N2 - Guidelines have been established for the physiological evaluation of lung cancer patients considered for surgery. While some recommend routine measurement of DLCO, others require this measure if there is evidence of interstitial disease, relying on FEV1 alone in most cases. Our objective in this study was to evaluate if radiologic evidence of interstitial disease is a good predictor of disparities between FEV1 and DLCO.We studied a sample of 50 patients with NSCLC referred to perform lung function measurement. Based on chest CT, patients were divided into two groups according to presence of interstitial disease. The correlation between FEV1 and DLCO was tested.48 individuals completed the study. 11 patients had diffuse interstitial disease in CT (Group ICT) while 37 patients had no signs of interstitial pattern (Group NCT). Both groups were similar in terms of age, gender and BMI. Mean DLCO% predicted was lower in ICT group 42 x 61% (p<0.01). VEF1 and TLC were also significantly lower in ICT. 7 patients in ICT and 32 in NCT had an obstructive pattern on spirometry (p=NS).FEV1 and DLCO had a significant correlation (R=0,376 p=0,009). The same analysis for both groups showed that FEV1 and DLCO correlated better in ICT (R=0,630 p=0,03) than in NCT (R=0,249 p=NS). In NCT group, 10 from 14 patients with normal FEV1 had impaired diffusion capacity.Interstitial infiltrate predicts impaired lung function and diffusion capacity but disparities between FEV1 and DLCO are more frequent in lung cancer patients without diffuse interstitial pattern. These findings support the routine assessment of DLCO in patients who are candidates for surgical treatment of NSCLC. ER -