PT  - JOURNAL ARTICLE
AU  - Yoko Yumino
AU  - Satoko Fujii
AU  - Naoki Takasaka
AU  - Jun Kojima
AU  - Hiromichi Hara
AU  - Takanori Numata
AU  - Takeo Ishikawa
AU  - Makoto Kawaishi
AU  - Keisuke Saito
AU  - Jun Araya
AU  - Katsutoshi Nakayama
AU  - Kazuyoshi Kuwano
TI  - The evaluation of systemic inflammation in COPD patients comorbided with cardiovascular diseases or diabetes mellitus
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p1024
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p1024.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p1024.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Background: COPD is one of so-called life-style related diseases and reported to show systemic inflammation, due to strong relationship to long-time tobacco smoking. Therefore, COPD patients often have a variety of comorbid diseases, including cardiovascular diseases (CVD), diabetes mellitus (DM), and other systemic diseases.Purpose: To investigate smoking status and frequency of comorbid COPD among the patients with CVD, DM, or both, who had smoking history (>10 pack×years), and also to investigate how CVD, DM or COPD is associated with systemic inflammation, oxidative stress and clinical disorders.Method: Totally 83 patients, over 40 years with history of cigarette smoking, were recruited for this study. All the participants were examined for pulmonary function test with bronchodilator, urine 8-OHDG/Creatinine, plasma levels for TNF-α, hs-CRP and pentosidine as predictors of airway obstruction, oxidative stress and systemic inflammation.Results: 11 in the 21 patients with CVD (52.4%) were diagnosed as COPD, 14 in 37 with DM (37.8%), and 9 in 25 with both (36.0%). Further analyses on the associations between each disease and systemic inflammation or oxidative stress were performed by logistic multivariate analyses adjusted with age, sex, smoking history, statin use, and each disease. As the results, Systemic inflammation evaluated by hsCRP increased significantly with statin use. The risk of oxidative stress evaluated by 8-OHdG increased approximately 3 fold with COPD.Conclusions: Because the smokers with DM or CVD seem to have much higher risk of COPD than smokers without them, they should be examined with pulmonary function test.