PT  - JOURNAL ARTICLE
AU  - Elena Yu Ponomareva
AU  - Elena E. Arkhangelskaya
AU  - Andrey P. Rebrov
TI  - Pulmonary hypertension in patients with infective endocarditis
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p2324
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p2324.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p2324.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Aim and methods: To study pulmonary hypertension (PH) in infective endocarditis (IE) pts with different localization, valve injury and activity of disease we have investigated 136 pts with native valve IE, in which 102 (75%) had left and 34 (25%) – sided IE. Diagnosis of IE was made according to Duke-criteria (ECS, 2009). Pulmonary artery systolic pressure (PASP) was measured using trans-thoracic EchoCG in dynamics taking into account the systolic tricuspid gradient and right atrium pressure.Results: PH was revealed in 132 pts with IE (97%). Mean PASP was 53,7±16,2 mmHg. Pts with minimal and moderate PH prevailed (1st degree PH in 61 pts (45%), 2d degree – in 50 pts (37%)), only 15% pts (21) proved high degree PH (PASP> 70 mmHg). No significant differences of PH level were found depending on the gender, age, left or right-sided localization of IE, acute stage or 1-year or more advanced stage of disease duration. Nevertheless the PH degree was significantly higher in the group of pts with bi-valve or multiple valve injury in comparison with group of pts with mono-valve pathology (61,3±15,8 vs 49,3±14,9, p<0,001). Among haemodynamic factors influencing the PASP most possible were left atrium diastolic size (R=0,556386, p=0,00001) and myocardium mass index (R=0,47, p<0,0001).Conclusions: So PH naturally develops in pts with IE and haemodynamic factors proved to be most significant in its development.