TY - JOUR T1 - Diagnostic accuracy of sputum induction test compared with bronchoscopic results in patients with pulmonary tuberculosis JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p4391 AU - Yunseong Kim AU - Doosoo Jeon AU - Kwangha Lee AU - Kiuk Kim AU - Hyekyung Park AU - Minki Lee AU - Soonkew Park Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p4391.abstract N2 - Rationale: Diagnosis of pulmonary tuberculosis is difficult in patient who do not produce sputum spontaneously, or who have AFB smear (-) sputum. Bronchoscopy is helpful in these patients, but in many cases cannot be readily available. We prospectively compared the diagnostic yield of sputum induction test with bronchoscopy.Methods: From February 1 to July 31, 2010, we included the patients suspected active pulmonary tuberculosis, who could not produce sputum spontaneously, or who had a pair of AFB smear (-) sputum. They underwent sputum induction test and bronchoscopy. We calculated the sensitivity of AFB smear, culture for Mycobacterium tuberculosis, TB-PCR of each test, and evaluated the concordance rate by kappa test.Results: Sensitivities of AFB smear were 36.1% in sputum induction test and 33.3% in bronchoscopy. Sensitivities of culture for Mycobacterium tuberculosis were 69.4% and 75.0%, and TB PCR were 52.8% and 58.3% in sputum induction and bronchoscopy, respectively. The results of AFB smear by sputum induction and bronchoscopy were concordant in 94% (63/67case, Kappa test=0.819). In culture for Mycobacterium tuberculosis, the results were concordant in 82% (54/67case, Kappa test=0.684) and the results of TB-PCR were concordant in 88% (59/67case, Kappa test=0.715).Conclusions: In this study, sputum induction test had shown similar diagnostic value and sensitivity with bronchoscopy in the diagnosis of active pulmonary tuberculosis. In patients who are difficult in collecting sputum, or have AFB smear-negative sputum, sputum induction test can be an alternative approach to the diagnosis of active pulmonary tuberculosis. ER -