RT Journal Article
SR Electronic
T1 Lung function differences between subjects with tobacco smoke-induced COPD (TS-COPD) and biomass smoke-induced COPD (BS-COPD) in an Indian population
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p918
VO 38
IS Suppl 55
A1 Bill Brashier
A1 Nitin Vanjare
A1 Vandana Vincent
A1 Jyoti Londhe
A1 Sapna Madas
A1 Sanjay Juvekar
A1 Peter Barnes
A1 Sundeep Salvi
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p918.abstract
AB Exposure to biomass fuel smoke is as an important risk factor for COPD (BS-COPD), but it is not known whether this phenotype is different from tobacco-smoke induced COPD (TS-COPD) with reference to lung physiological changes.Aim: To compare lung function profiles between subjects with BS-COPD and TS-COPD.Methods: 17 BS-COPD (mean 43 yrs exposure) and 35 TS-COPD (mean 43 smoking pack yrs) subjects underwent pre and post bronchodilator spirometry to measure FEV1, FVC and FEF25-75%, bodyplethysmography to measure residual volume (RV) and total lung capacity (TLC), impulse oscillometry (IOS) to measure R5Hz and R20Hz and single-breath DLCO to measure lung diffusion. Two sample “t” test was used to compare mean (±SD) lung function parameters between the two groups.Results: There were no significant differences in% predicted values for FEV1, FVC, R20Hz, RV and TLC between TS-COPD and BS-COPD (all p values >0.05). However, BS-COPD showed a trend towards greater small airway obstruction indicated by lower FEF25-75% predicted values [BS: 9% (±3%) vs TS: 12% (±5%), p= 0.02], higher R5Hz% predicted values [BS: 272% (±65%) vs TS: 222% (±94%), p= 0.05] and higher R5-20Hz values normalised to total airway resistance [BS: 0.53 (±0.07) vs TS: 0.46 (±0.13) p=0.05], while TS-COPD showed lower% predicted values for DLCO [TS: 53% (±24%) vs BS: 71% (±33%); p=0.03].Conclusion: BS-COPD shows similar decrements in Spirometric, IOS and body plethysmographic parameters as TS-COPD. However, BS-COPD was associated with greater small airways obstruction, while TS-COPD was associated with lower DLCO values.