TY - JOUR T1 - Albuminuria in children with obstructive sleep apnea JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p3046 AU - Vasiliki Varlami AU - Emmanouel Alexopoulos AU - Georgia Malakasioti AU - Vasiliki Theologi AU - Eleni Theophanous AU - Athanasios Kaditis AU - Efthimia Daskalopoulou AU - Konstantinos Gourgoulianis Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p3046.abstract N2 - Increased excretion of albumin in urine has been considered a surrogate marker of endothelial dysfunction in adults with obstructive sleep apnea (OSA). Aim of this study was to evaluate urinary excretion of albumin in children with OSA.Methods: Albumin-to-creatinine ratio (ACR) was calculated in a morning urine specimen collected from children with or without OSA. An assay appropriate for detection of microalbuminuria was used.Results: Twenty seven subjects with moderate-to-severe OSA (5.6±2.1 y.o.; AHI 9.1±3.7 episodes/h), 71 subjects with mild OSA (6.2±2.3 y.o.; 2.4±1 episodes/h) and 31 children without habitual snoring (6.7±2.4 y.o.; 0.6±0.3 episodes/h) were studied. Subjects with moderate-to-severe OSA had similar ACR to those with mild OSA (p=0.072) and significantly higher ACR relative to subjects without habitual snoring (p=0.007): median 0.38 (0-14.3) mg/g vs. 0.31 (0-13) vs.0 (0-3.26), respectively. There was significantly increased risk for having ACR>0 in children with moderate-to-severe or mild OSA compared to children without habitual snoring after adjustment for age and gender: OR (95% CI) 6.4 (1.8-23.3) or 2.7 (1.1-6.9) vs. 1.0.Conclusions: Children with OSA are at increased risk for having detectable morning abuminuria. ER -