PT  - JOURNAL ARTICLE
AU  - Juan de Torres
AU  - Jose Marin
AU  - Ciro Casanova
AU  - Claudia Cote
AU  - Santiago Carrizo
AU  - Elizabeth Cordoba Lanus
AU  - Rebeca Baz Davila
AU  - Javier Zulueta
AU  - Armando Aguirre Jaime
AU  - Marina Saetta
AU  - Manuel Cosio
AU  - Bartolome Celli
TI  - Lung cancer in patients with COPD: Incidence and predicting factors
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p2728
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p2728.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p2728.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Background: Little is known about the clinical factors associated with development of lung cancer in patients with Chronic Obstructive Pulmonary Disease (COPD).Objective: To explore incidence, histological type and factors associated with development of lung cancer diagnosis in a cohort of patients with COPD.Methods: A cohort of 2507 patients without initial clinical or radiological evidence of lung cancer was followed for 62±38 months. At baseline, anthropometrics, smoking history, lung function and body composition were recorded. Time to diagnosis and histological type of lung cancer was then registered. Multivariate Cox analysis were used to explore factors associated with lung cancer diagnosis.Results: Incidence density of lung cancer was 16.7 cases/1000 person-years. The most frequent histological type was squamous cell carcinoma (44%).Conclusions: Incidence density of lung cancer is high in COPD patients and occurs more frequently in older patients with milder airflow obstruction (GOLD stages I and II), a DLCO <80% and lower BMI. Knowledge of these factors may help direct efforts for early detection of lung cancer and disease management.