PT  - JOURNAL ARTICLE
AU  - Edgar, Ross
AU  - Griffiths, Diane
AU  - Sapey, Elizabeth
AU  - Stockley, Robert
TI  - Investigating change in the COPD assessment test (CAT) within α-1 antitrypsin deficiency (A1ATD)
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p3514
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p3514.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p3514.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Introduction: The COPD Assessment Test (CAT) has been validated in COPD as a health status questionnaire (HSQ). Our group has validated the CAT in A1ATD, with correlations between CAT score and total St Georges Respiratory Questionnaire score (SGRQ) (R2=0.81, p<0.001, n=320). Associations between CAT scores and lung function mirrored those seen with the SGRQ. We wished to determine if CAT could identify changes in health status over time and whether this correlated with differences in total SGRQ scores and its domains.Method: 34 clinically stable patients with A1ATD attending the ADAPT centre annually completed both SGRQ and CAT prior to lung function and medical review. Demographics: 21 male (62%), mean age 54yrs (range 25-82), mean FEV1% pred 57 (range 23-123), mean KCO% pred 58 (range 29-95).Result: Over the two time points, there was a significant change in CAT score compatible with a worsening of health status (mean difference 1.65 (SEM 0.83) p=0.03) and a significant change in mean total SGRQ score (mean difference 2.91 (SEM 1.7) p=0.04). There were no changes in mean domain scores.A significant correlation between the change in total SGRQ and CAT scores over 1 year (p=0.002) was observed. There were no difference in sensitivity of change indices, SGRQ 1.71 and CAT 1.99 and no differences in clinical or physiological parameters over the 2 time points.Conclusion: Both CAT and total SGRQ scores increased within our patient group over one year. Changes in total SGRQ and CAT scores correlated significantly suggesting that the CAT can be used as an HSQ to track change over time in A1ATD. Further recruitment will allow us to correlate CAT scores with decline.