RT Journal Article
SR Electronic
T1 Are systemic inflammatory markers predictive of loss of lean body mass in COPD patients?
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p1764
VO 38
IS Suppl 55
A1 Tomas M.L. Eagan
A1 Esteban Gabazza
A1 Corina D'Alessandro-Gabazza
A1 Jon A. Hardie
A1 Per S. Bakke
A1 Peter D. Wagner
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p1764.abstract
AB Background: Previous studies suggest a relationship between systemic inflammation and body composition in COPD.Methods: We examined the relationships between four plasma inflammatory markers; C-Reactive Protein (CRP), Tumor Necrosis Factor (TNFα), and interleukins 1&6 (IL-1, IL-6) and body composition (fat free mass index (FFMI, kg/m2), and fat mass index (FMI, kg/m2)) in 409 stable COPD patients (aged 40-75, GOLD categories II-IV, 249 male) from the Bergen COPD Cohort Study in Western Norway. Levels of the four plasma markers were determined by enzymeimmunoassays (EIAs) from samples taken at baseline, and after one and two years of follow-up. FFMI and FMI were measured by bioelectrical impedance at baseline, and after one, two and three years.Results: None of the four markers were significantly related to FFMI at baseline, either when modeled as categorical or continuous variables. CRP was significantly associated with FMI at baseline, where mean (SD) FMI in the three CRP categories 0-1 ug/mL, 1-4 ug/mL, and 4+ ug/mL was 8.1 (2.4), 10.8 (4.3), and 12.5 (5.5) in men and 6.6 (1.7), 7.4 (2.7), and 8.4 (3.0) respectively. TNFα, IL-1, and IL-6 showed no association with baseline FMI.Examining the predictive value of the four markers for 3-yr change in body composition, no significant associations were found. For example, mean (SD) 3-yr change in FFMI was -0.09 (0.88), -0.23 (0.81), and -0.07 (0.90) in women (p=0.63) for the three CRP categories, and -0.12 (1.15), -0.22 (1.47), and 0.15 (1.71) in men (p=0.28).Conclussion: Of the four systemic inflammatory markers CRP, TNF, IL-1, IL-6; CRP only was related to body composition (FMI, not FFMI) at baseline. No marker predicted change in FFMI or FMI.