RT Journal Article
SR Electronic
T1 Hemodynamic effects of non-invasive ventilation in patients with obesity-hypoventilation syndrome
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p2085
VO 38
IS Suppl 55
A1 Olalla Castro-Añόn
A1 Rafael Golpe
A1 Luis A. Pérez-de-Llano
A1 María J. Lόpez
A1 Edgar Escalona
A1 Ruth Pérez-Fernández
A1 Ana Testa
A1 Arturo González Quintela
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p2085.abstract
AB Background: Although it was occasionally reported that pulmonary hypertension (PH) is more frequent in obesity-hypoventilation syndrome (OHS) patients than in “pure” obstructive sleep apnea syndrome (OSAS) patients, little is known about the haemodynamic repercussion of this entity. The aim of this study was to describe the hemodynamic situation -assessed by echocardiography and six-minute walking test (6MWT)- of patients newly diagnosed with the most severe form of OHS and to evaluate the impact of non-invasive ventilation (NIV) on it.Methods: We conducted a prospective, descriptive, single-center follow-up study. At baseline, patients underwent echocardiography, spirometry, static lung volumes measurement, 6MWT, overnight pulse-oximetry and polygraphic recording. We assessed changes in echocardiographic findings and 6MWT after 6 months of NIV implementation. Right ventricular overload (RVO) was defined by the presence of right ventricular (RV) dilatation, RV hypokinesis, paradoxical septal systolic motion or/and PH.Results: A total of 30 subjects (20 women; mean age: 69±11 years) were included. The percentage of patients with RVO did not change significantly after NIV (from 43.3% to 41.6%; p = 0.24). Pulmonary artery systolic pressure (PASP) for patients with RVO at diagnosis decreased significantly at 6 months (from 58±11 to 44±12 mmHg; p= 0.014) and the mean distance walked on the 6MWT increased from 350±110 to 426±78 m (p = 0.006) without significant changes in the body mass index.Conclusions: PH is a frequent finding in patients with the most severe form of OHS. Treatment with NIV leads to a decrease in PASP and an increase in the distance covered during the 6MWT.