TY - JOUR T1 - Hemodynamic effects of non-invasive ventilation in patients with obesity-hypoventilation syndrome JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p2085 AU - Olalla Castro-Añόn AU - Rafael Golpe AU - Luis A. Pérez-de-Llano AU - María J. Lόpez AU - Edgar Escalona AU - Ruth Pérez-Fernández AU - Ana Testa AU - Arturo González Quintela Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p2085.abstract N2 - Background: Although it was occasionally reported that pulmonary hypertension (PH) is more frequent in obesity-hypoventilation syndrome (OHS) patients than in “pure” obstructive sleep apnea syndrome (OSAS) patients, little is known about the haemodynamic repercussion of this entity. The aim of this study was to describe the hemodynamic situation -assessed by echocardiography and six-minute walking test (6MWT)- of patients newly diagnosed with the most severe form of OHS and to evaluate the impact of non-invasive ventilation (NIV) on it.Methods: We conducted a prospective, descriptive, single-center follow-up study. At baseline, patients underwent echocardiography, spirometry, static lung volumes measurement, 6MWT, overnight pulse-oximetry and polygraphic recording. We assessed changes in echocardiographic findings and 6MWT after 6 months of NIV implementation. Right ventricular overload (RVO) was defined by the presence of right ventricular (RV) dilatation, RV hypokinesis, paradoxical septal systolic motion or/and PH.Results: A total of 30 subjects (20 women; mean age: 69±11 years) were included. The percentage of patients with RVO did not change significantly after NIV (from 43.3% to 41.6%; p = 0.24). Pulmonary artery systolic pressure (PASP) for patients with RVO at diagnosis decreased significantly at 6 months (from 58±11 to 44±12 mmHg; p= 0.014) and the mean distance walked on the 6MWT increased from 350±110 to 426±78 m (p = 0.006) without significant changes in the body mass index.Conclusions: PH is a frequent finding in patients with the most severe form of OHS. Treatment with NIV leads to a decrease in PASP and an increase in the distance covered during the 6MWT. ER -