PT  - JOURNAL ARTICLE
AU  - Makarevich, Alexander
AU  - Omelyanenko, Oksana
AU  - Amelchenko, Elena
AU  - Rybina, Tatyana
TI  - Interleukin-2 (IL-2) and interferon-γ(IF-γ) in idenitying severe community-acquired pneumonia (SCAP) clinical outcomes and complications
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p1474
VI  - 38
IP  - Suppl 55
4099  - https://publications.ersnet.org//content/38/Suppl_55/p1474.short
4100  - https://publications.ersnet.org//content/38/Suppl_55/p1474.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Background: Exaggerated and protracted proinflammatory response is associated with poor prognostic implications in SCAP.We assessed the diagnostic value of IL-2 and IFN-γ in identifying SCAP in-hospital outcomes and complications.Methods: 30 SCAP patients CURB-65 class 3,4 were enrolled. Control group included 16 comparable healthy volunteers. We performed X-ray examination, IL-2 and IFN-γ measurement within the first 24 hours after admission and on day 8. In-hospital mortality (IHM), need for vasopressor support (VS), SCAP complications (necrotising pneumonia (NP), pleural effusion (PE)) were analyzed.Results: Increasing CAP severity was associated with increased IL-2 values on the 1st day (r=0,64; p<0,05).IL-2 on admission values correlated with IHM (r=0,67; p<0,05). Patients with poor clinical prognosis had higher Il-2 levels on the 1st day vs those who survived [median][138 vs 20,8 pg/ml, p<0,05 respectively]. IL-2 on admission correlated with need for VS (r=0,65; p<0,05) and revealed higher concentrations in patients requiring VS vs those with stable haemodynamics [122 vs 19pg/ml, p<0,05].Patients who developed NP showed lower IL-2 levels vs those without destructive lung changes [16 vs 26 pg/ml, p<0,05]. PE in SCAP patients correlated with enhanced IFN-γ levels on the 1st and 8th days (r=0,8; p=0,01 and r=0,69; p=0,02). Patients with PE demonstrated higher IFN-γ values [41 and 20 pg/ml, p<0,05] vs those without PE [6,3 and 3,8 pg/ml, p<0,05].Conclusions: IL-2 on admission values are reliable for mortality risk stratification, prediction of need for VS and NP development, IFN-γ could be helpful in identifying PE complication in SCAP patients.