RT Journal Article
SR Electronic
T1 6-month follow-up in patients with advanced upper lobe predominant heterogeneous emphysema treated with endobronchial lung sealant therapy
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p3527
VO 38
IS Suppl 55
A1 Felix Herth
A1 Ralf Eberhardt
A1 Arschang Valipour
A1 Franz Stanzel
A1 Reiner Bonnet
A1 Juergen Behr
A1 Charles Marquette
A1 Mordechai Kramer
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p3527.abstract
AB Objective(s): Responses to AeriSeal® Emphysematous Lung Sealant System (ELS) therapy in patients with advanced upper lobe predominant heterogeneous (ULP) emphysema are summarized out to 6 months of follow-up.Methods: 14 patients with ULP emphysema received ELS treatment in a multi-center study conducted at 8 sites across Europe and Israel. Ten (10) of these patients underwent a second treatment session after 12 weeks in the contralateral upper lobe to complete bilateral therapy. Pulmonary function, functional capacity, and quality of life assessments were performed at 3 and 6 months following treatment.Results: Upper lobe ELS therapy in this cohort (8 male, age 63±6 yrs) was associated with improvements in pulmonary function, functional capacity, and quality of life. Three (3) and 6 month improvements in FEV1 (+17.4±33.1%; 20.3±33.3%), FVC (11.3±24.7%; 12.3±24.2%), RV/TLC ratio (-7.5±11.1%; -6.2±7.4%), MRCD (-0.3±0.83U; -0.4±0.77U), 6MWT (+22.4±105.9m; +31.6±80.6m), and SGRQ (-9.5±11.3U; -6.3±9.6U) were reported. Clinically significant improvements in spirometry were observed in 9 of 14 patients at 6 month follow-up. Physiological responses were best in those patients (n=10) who received bilateral upper lobe split dose therapy (ΔFEV1 = +24.8±36.8%; ΔFVC = +17.6±25.6%).Conclusions: ELS therapy in patients with advanced ULP emphysema improves lung function, functional capacity and quality of life out to at least 6 months. Improvements in spirometry following bilateral upper lobe therapy can be equivalent to those observed following lung volume reduction surgery.