PT  - JOURNAL ARTICLE
AU  - Franca Rusconi
AU  - Monica Da Frè
AU  - Virgilio Carnielli
AU  - Valeria Chiandotto
AU  - Carlo Corchia
AU  - Domenico Di Lallo
AU  - Mariacristina Fertz
AU  - Silvana Miniaci
AU  - Simone Piga
AU  - Marina Cuttini
TI  - Risk factors for lower respiratory illnesses (LRI) in infants < 32 wks gestational age (GA): Do they differ by type of illness?
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p1503
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p1503.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p1503.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Children born very preterm suffer from and are hospitalized for LRI. Risk factors for these events should be reassessed given advances in perinatal care.All infants 22-31 wks GA born in 2003-05 in 5 Italian regions (ACTION study) were invited for pediatric assessment and telephone interview at 24 mos corrected age. Bronchiolitis/asthmatic bronchitis and bronchitis/pneumonia in previous year, and lifetime LRI hospital admissions were recorded. Parental demographics and asthma/atopy, obstetrical and perinatal variables, breastfeeding and current environmental factors (siblings, smoking/dampness at home, traffic) were assessed as possible predictors through multivariable regression analysis.1009/1413 children had assessment+interview. Bronchiolitis/asthmatic bronchitis (18.8% of children) were significantly associated with lower GA, parental asthma (Odds ratio,OR 1.80) and day care (OR 2.00), while female sex and foreign mother were protective (OR 0.71 and 0.56). Risk of bronchitis/pneumonia (16.2%) was significantly reduced at higher GA, in twins (OR 0.45), and in infants discharged from NICU in april-september (OR 0.63). 14% of children were admitted to hospital for LRI; they were significantly more likely to have been exposed to maternal smoking in pregnancy (OR 1.67), have had birthweight <10° centile (OR 2.0) and BPD (OR 2.1); infants with LRI requiring O2 or ventilation (5.2%) had the same risk factors.Wheezing and LRI admissions had different risk profiles: the former were similar to those in general populations studies, while the latter were associated with prenatal factors influencing lung growth (intrauterine growth restriction, smoke) and BPD.