PT  - JOURNAL ARTICLE
AU  - Sherif Mohamed
AU  - Gamal Agmy
AU  - Yaser Gad
AU  - Esam Farghally
AU  - Hamdy Mohammedin
AU  - Hebba Rashed
TI  - Bacterial profile, antibiotic sensitivity and resistance of lower respiratory tract infections in upper Egypt
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p495
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p495.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p495.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Purpose: To identify causative bacteria,antibiotic sensitivity/resistance of lower respiratory tract infections (LRTIs) in Upper Egypt.Methods: A multicentre prospective study was performed. Sampling was done for all patients including,sputum and/or BAL for Gram stain and culture. Samples were cultured on 3 media (Nutrient,Chocolate and MaConkey's agars).Indirect Fluorescent Antibody was used to detect atypical pathogens.Results: Predominant isolates in patients with CAP were S.pneumoniae (36%), C.pneumoniae(18%), M. pneumoniae(12%) and K. pneumoniae (10%). A higher sensitivity was recorded for moxifloxacin, levofloxacin, macrolides, and cefepime. A higher rate of resistance was recorded for tetracyclines, cephalosporins, lincomycin, and β-lactam-β-lactamase inhibitor. Predominant isolates in patients with HAP were, MRSA (23%), K.pneumoniae (14%),E.coli(11%), P.aeruginosa (9%). A higher sensitivity was recorded for vancomycin,amikacin,and respiratory quinolones.An absolute resistance was recorded for β-lactam-β-lactamase inhibitor,high rates were recorded for cephalosporins.Predominant isolates in patients with AECOPD were H.influnzae (30%), S.pneumoniae (25%), M.catarrhalis (18%), K.pneumoniae (12%) and C. pneumoniae (5%). A higher sensitivity was recorded for quinolones,macrolides and cefepime. High resistance was recorded for amikacin,clindamycin, and cephalosporins.Conclusion: The most predominant bacteria for CAP in Upper Egypt are S.pneumoniae and atypical organisms,while that for HAP are MRSA and Gram negative bacteria. For AECOPD,H.influnzae is the commonest. Respiratory quinolones,linezolides,and cefepime are the most efficient antibiotics in treatment of LRTIs in our locality.