PT  - JOURNAL ARTICLE
AU  - Evgeny Kulikov
AU  - Ludmila Ogorodova
AU  - Ivan Deev
TI  - Efficiency of different strategies of asthma control achievement in real clinical practice
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p889
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p889.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p889.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Introduction: Epidemiological studies registered the asthma control prevalence in the population at 5% on average but controlled studies showed that control achievement is possible in more than 70% of patients. There is no clear what part of asthma patients can have controlled asthma and which therapy regimen will be optimal in real clinical practice.Aim: To compare the efficiency of strategies of control achievement in patients with persistent asthma in real clinical practice.Methods: Multicenter prospective 24-week observation study was conducted in 19 centers in Russia. The following data were collected: ACT score, FEV1, therapy changes, number of emergency visits. The investigator was only to record the changes of therapy prescribed by the physician of patient. Patients were aposterior stratified into three groups: A – step-up regime of combined therapy (salmeterol/fluticasone propionate), B – stable regime, C – step-down regime.Result: At the end of the observation disease control criteria in group A was achieved in 73,3% of cases, 69,4% in group B, and 58,5% in group C. The positive FEV1 dynamics was registered in the group A and group B – 6.4±1.5% and 5.0±1.5%, respectively. There was the negative dynamics of the FEV1 in group C (-8.2±2.8). Using of A and B strategies increased the probability of the full control achievement 3 times in comparison with the Group C (OR 3.27; 95%CI 1.48-7.35 and OR 3.36; 95%CI 1.53-7.54, respectively). Highest emergency visits frequency was registered in the group C (18,2%; Group A - 2.6% and B - 5.8% (p<0.001 vs A; p=0.01 vs B).Conclusion: In the real clinical practice the use of combination therapy at step-up dose or in stable dose are optimal.