TY - JOUR T1 - The changes of serum adipocytokines levels in patients with OSAHS JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p2270 AU - Yong Lin AU - Ting Xu Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p2270.abstract N2 - Background: Obstructive sleep apnea hypopnea is associated with obesity. Adipocytokines which were secretioned by fatty tissue can influence energy metabolism all over the body and development of obesity. Apelin, NPY and A-FABP were adipocytokines discovered for the past few years. They may participate the generation and development of OSHAS, especially obesity combined OSAHS.Objective: To investigate the relationship between adipocytokines (Apelin, NPY and A-FABP) and obstructive sleep apnea-hyperpnoea syndrome (OSAHS).Methods: Patients underwent polysomnography were recruited and divided into OSAHS group and non-OSAHS group. Each group was divided into obesity, hypergravity and normal body weight arms according BMI. OSAHS group was divided into mild, moderate and severe arms. Plasma Apelin, NPY, A-FABP (ng/ml) levels of all arms were tested and compared.Results: Plasma adipocytokines Apelin, NPY and A-FAPB levels were significantly higher in OSAHS group than in the non-OSAHS group of same weight, independent of age and gender. These adipocytokines plasma levels were positively correlated with AHI, BMI, while negatively correlated with LSaO2 and MSaO2 in OSAHS group.Conclusions: Obesity can cause the increase of plasma Apelin, NPY and A-FABP levels. These three adipocytokines were positively cforrelated with the severity degree of OSAHS. ER -