RT Journal Article SR Electronic T1 Serum lipid profile and iron content in serum and pulmonary tissue in experimental pulmonary emphysema JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP p422 VO 38 IS Suppl 55 A1 Snezana Zunic-Bozinovski A1 Svetlana Zunic A1 Slavko Vucicevic A1 Ivan Milovanovic A1 Danica Djarmati A1 Gordana Djordjevic-Denic YR 2011 UL http://erj.ersjournals.com/content/38/Suppl_55/p422.abstract AB Disturbed lipid metabolism and some trace elements, including iron, may be involved in pathogenesis of experimental pulmonary emphysema via different mechanisms. We studied serum lipid profile and iron content in serum and pulmonary tissue of rabbits with experimental pulmonary emphysema. The study was done on three groups of animals: E (n=16) – experimental group on hypercholesterolemic diet (4% crystalline cholesterol in edible oil solution), C (n=16) – control group on standard diet for that animal species, and O (n=13) – group on oily diet. Serum lipid profile (total cholesterol, triglycerides, HDL, VLDL and LDL cholesterol fractions) was determined by enzymatic colorimetric method and iron content in serum and pulmonary tissue by atomic absorptive spectrophotometric method. Pulmonary emphysema was pathohistologicaly confirmed. There was a significant increase in total serum cholesterol (p<0.001 and p<0.05 respectively) and LDL cholesterol (p<0.001) in E compared to both C and O group. Serum iron concentration was increased in E in comparison with C group (p<0.05). In pulmonary tissue iron content was decreased in both E and O group compared to C group (p<0.01 and p<0.001 respectively), as well as in O in comparison with E group (p<0.001). The results of present study indicate that disturbed lipid metabolism and iron content alterations could be in association with oxido-reductive and metabolic disbalance, connected to emphysematous alterations in pulmonary tissue of investigated animals.