RT Journal Article
SR Electronic
T1 Gender-dependent characteristics of sleep-disordered breathing in chronic heart failure
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p1750
VO 38
IS Suppl 55
A1 Holger Woehrle
A1 Gerhard Weinreich
A1 Michael Arzt
A1 Olaf Oldenburg
A1 Karl Wegscheider
A1 Erland Erdmann
A1 Helmut Teschler
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p1750.abstract
AB Background: Sleep-disordered breathing (SDB) is common in patients with chronic heart failure (CHF) and influences the progression of the disease. Large multi-centre studies are missing yet.Methods: In the ongoing prospective multi-centre SchlaHF registry we studied so far 1,273 CHF patients diagnosed by gold standard polysomnography (PSG). New York Heart Association (NYHA) class was ≥II and left-ventricular ejection fraction (LVEF) ≤45%. Patients were screened with a two-channel device and referred to a sleep laboratory in case of suspected SDB. Using PSG we studied sleep and SDB characteristics in these referred CHF patients. SDB was defined as apnea-hypopnea index (AHI) >15/h.Results: Gender-dependent sleep efficiency was similar in central sleep apnea (CSA) (m: 75.6%, f: 76.2%, n.s.), obstructive sleep apnea (OSA) (m: 73.8%, f: 70.4%, n.s.) and in patients without SDB (m: 76.0%, f: 73.9%, n.s.). The same results we found for sleep duration in CSA (m: 317min, f: 324min, n.s.), OSA (m: 313min, f: 294min, n.s.) and no SDB (m: 320min, f: 312min, n.s.). We studied AHI in CSA (m: 38.1/h, f: 32.6/h, n.s.), OSA (m: 38.0/h, f: 34.9/h, n.s.) and in patients without SDB (m: 8.5/h, f: 9.0/h, n.s.). Significant gender-dependent differences were found in the respiratory subindices: apnea-index (AI) in CSA (m: 23.8/h, f: 14.5/h, p<0.05), OSA (m: 22.4/h, f: 14.5/h, p<0.05) and in patients without SDB (m: 3.7/h, f: 3.2/h, n.s).Conclusions: In the SchlaHF registry sleep duration and sleep efficiency were similar both in men and women regarding CSA, OSA and patients without SDB. Gender-dependent differences were found in the subindices AI and HI.