RT Journal Article
SR Electronic
T1 Right ventricular diastolic stiffness in idiopathic pulmonary arterial hypertension
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p2317
VO 38
IS Suppl 55
A1 Rain, Silvia
A1 Kind, Taco
A1 Handoko, Louis
A1 Boerrigter, Bart
A1 Westerhof, Nicolaas
A1 van der Velden, Jolanda
A1 Vonk-Noordegraaf, Anton
A1 de Man, Frances
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p2317.abstract
AB Introduction: Idiopathic pulmonary arterial hypertension (iPAH) is a fatal disease with grim prognosis due to subsequent development of right heart failure (RHF). Findings in experimental pulmonary hypertension models suggest RHF is associated with increased diastolic stiffness.Objective: This study investigates whether right ventricle (RV) diastolic stiffness is increased in iPAH patients.Methods: Right heart catheterization (RHC) and MRI were performed in 28 patients suspected with iPAH. Based on pulmonary artery pressure, patients were divided into controls (7) and iPAH (21). Diastolic elastance (diastolic stiffness), was quantified by the slope of diastolic pressure-volume relation, constructed by plotting RV end-systolic volumes and begin-diastolic pressures against RV end-diastolic volumes and end-diastolic pressures. Subsequently, we investigated whether diastolic elastance was associated with disease severity by comparing patients with lower RV stoke volumes (RVSV) and patients with higher RVSV.Results: Diastolic elastance was significantly altered in iPAH (iPAH 0.25±0.04 vs. Con 0.07±0.006, p=0.024). In addition, patients with lower RVSV had significantly higher diastolic elastance (LowSV0.38±0.05 vs HighSV 0.114±0.02).Conclusion: This study demonstrates that RV diastolic stiffness is increased in iPAH-patients and is associated with disease severity. In future studies we will investigate the prognostic relevance of these changes.