RT Journal Article SR Electronic T1 Maintenance of long term benefits from an outpatient pulmonary rehabilitation programme in COPD JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP p3644 VO 38 IS Suppl 55 A1 Francesco Costa A1 Laura Malagrinò A1 Sandra Antonelli A1 Claudia De Simone A1 Giovanna Decusatis A1 Dario Nieri A1 Sabrina Santerini A1 Barbara Vagaggini A1 Pierluigi Paggiaro YR 2011 UL http://erj.ersjournals.com/content/38/Suppl_55/p3644.abstract AB We evaluated the long term manteinance of benefits of a Pulmonary Rehabilitation Programme (PRP) in COPD patients and to establish which patients require frequent repetitions of PRP.Fifty-one COPD patients (FEV1: 57±17%) underwent 10 weeks outpatient PRP comprehensive of supervised exercise training on cycloergometer and upper limb training. Pre-PRP (T0), post-PRP (T1), 6 months (T2) and 9 months (T3) after the end of PRP we measured: exercise tolerance by 6 minute walking test (6MWT), dyspnoea by MRC, quality of life by St George Respiratory Questionnaire (SGRQ).All outcomes improved at T1. 6MWT and MRC progressively worsened at T2 and T3 respectively, whereas SGRQ remanained stable up to 9 months from PRP.View this table:The correlation between the baseline indices and the rate of deterioration at T3 demonstrated that a worst MRC at T0 is a good predictor of an early increase of dyspnoea perception after PRP cessation (r=0.30, p=0.03).When patients were subdivided in responders (N=17) and in non Responders (N=34) to PRP according to an increase in 6MWT of 54 mt, responders showed a greater decline of benefits in exercise tolerance at T3 in comparison with non responders (T1-T3 6MWT: 49.4±66.9 vs 12.3±58.4 mt, p<0.05). Responders had a baseline 6MWT significantly lower than non responders (430±121mt vs 452±116 mt, p<0.05).In conclusion, COPD patients with worst physical performance at baseline have better results from PRP, but they loose benefits more quickly than other ones. As previously reported, benefits in quality of life and dyspnoea persist longer than exercise tolerance.