TY - JOUR T1 - Anti-inflammatory nutritional support enhances exercise performance and QOL in patients with stable COPD JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - 1893 AU - Keiyu Sugawara AU - Takanobu Shioya AU - Masahiro Satake AU - Atsuyoshi Kawagoshi AU - Hitomi Takahashi AU - Takeshi Kashiwagura AU - Kohko Yamada AU - Kazuo Dairiki AU - Hajime Sasaki AU - Mitsunobu Homma Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/1893.abstract N2 - Purpose: This study was conducted to investigate the effect of nutritional support using whey protein-rich supplement which has an anti-inflammatory effect on exercise performance and QOL, and systemic inflammation in stable COPD.Methods: Thirty-six patients with stable COPD (mean (SD) age 77.2 (5.8)yrs, FVC 2.70 (0.72)L, FEV1 1.10 (0.44)L,%predicted FEV1 44.5 (16.2)%, FEV1/FVC 44.5 (16.9)%) were studied. COPD patients under continuing pulmonary rehabilitation (PR) were randomly divided into a nutrition group and a control group (education only). In nutrition group whey protein-rich supplement (400 kcal/day) was supplied for 12 weeks. Whey protein, a protein complex derived from milk, has been shown to have a strong anti-inflammatory effect in vitro. PR program consisted of respiratory muscle (RM) stretch gymnastics, RM training, breathing retraining, chest wall mobilization, and chair exercise. Lung functions, six-minute walking distance (6MWD), chronic respiratory questionnaire (CRQ), and inflammatory biomarkers (hsCRP, TNFα, IL-6, IL-8) were evaluated before and 12 week after nutritional intervention.Results: In the nutrition group, inflammatory markers decreased significantly (hsCRP; 2.7 (3.4) vs 1.5 (2.0)mg/L (p<0.01), TNFα; 1.2 (0.4) vs 1.2 (0.4)pg/ml, IL-6; 2.7 (1.4) vs 2.2 (1.1), IL-8; 2.0 (1.3) vs 1.1 (1.1)pg/ml (p<0.01)). 6MWD increased significantly from 322 (183) to 368 (182)m (p<0.01). The total values of CRQ also increased from 103 (16) to 109 (17).Conclusions: We conclude that anti-inflammatory nutritional support using whey protein-rich supplement might enhance exercise capacity and QOL in stable COPD by improving systemic inflammation. ER -