PT  - JOURNAL ARTICLE
AU  - Yasuyuki Ikezawa
AU  - Naofumi Shinagawa
AU  - Taichi Takashina
AU  - Kenichiro Ito
AU  - Iki Ogura
AU  - Yutaka Takeuchi
AU  - Noriyuki Yamada
AU  - Hajime Asahina
AU  - Jun Sakakibara-Konishi
AU  - Satoshi Oizumi
AU  - Kosuke Nakano
AU  - Noriaki Sukoh
AU  - Masaharu Nishimura
TI  - Usefulness of endobronchial ultrasonography with a guide sheath for diagnosing ground glass opacity lesions
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - 4522
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/4522.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/4522.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Background and purpose: It is often hard to diagnose ground glass opacity (GGO) lesions by transbronchial biopsy (TBB), because of difficulty in detecting the site of the lesions under X-ray fluoroscopy. We have reported the usefulness of TBB using endobronchial ultrasonography with a guide sheath (EBUS-GS) for small peripheral pulmonary lesions (PPLs). EBUS-GS has an advantage to detect the location of PPLs. In this study, we retrospectively analyzed the diagnostic yield of GGO lesions by EBUS-GS and examined of lesions which might influence the diagnostic yield.Patients and methods: Between August 2003 and December 2007, we performed EBUS-GS for a total of 67 GGO lesions in Hokkaido University Hospital and Hokkaido Cancer Center.Results: Of the 67 lesions (11 pure GGO lesions and 56 mixed GGO lesions, which consist of GGO components more than 50%), 43 (64%) were not visible by conventional X-ray fluoroscopy. Thirty-eight lesions were diagnosed by TBB with EBUS-GS (36 adenocarcinoma, 1 lymphoma and 1 inflammation). The average size of lesions with diagnosis was significantly larger than that of lesions without definitive diagnosis. (23.9mm vs. 16.7mm; P<0.01) For lesions with bronchus leading directly to the center of the lesions on high-resolution computed tomography images (positive CT sign), the diagnostic yield was significantly higher than lesions with negative CT sign. (31% vs. 66%; P < 0.01)Conclusion: EBUS-GS is a useful method for diagnosing GGO lesions. However, failure of diagnosis is associated with the lesions in smaller size and/or with negative CT sign.