RT Journal Article
SR Electronic
T1 Tracheobronchopathia osteochondroplastica: End stage of tracheo bronchial amyloidosis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p3605
VO 38
IS Suppl 55
A1 Houda Gharsalli
A1 Saloua Azzabi
A1 Besma Ourari Dhahri
A1 Walid Feki
A1 Soumaya Rammeh Rommani
A1 Mohamed Ali Baccar
A1 Jihéne Ben Ammar
A1 Meizar Salah Said
A1 Leila El Gharbi
A1 Hichem Aouina
A1 Hend Bouacha
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p3605.abstract
AB Introduction: Tracheobronchopathia osteochondroplastica (TO) is an uncommon benign disease affecting the cartilaginous wall of large airways. Etiology of TO is unknown, however review of literature reveals an intimate interrelationship between TO and amyloidosis and many authors suggest that TO is an advanced stage of primary tracheobronchial amyloidosis. We describe a case illustrated TO as an end stage of amyloidosis.Case report: A 47 year old nosmoker woman was admitted in1997 for dyspnea reported since 2 years. Pulmonary function test showed an obstructive pattern. Asthma was suspected but we haven't amelioration of symptoms with appropriate treatment. Fiberoptic bronchoscopic examination revealed infiltration and nodular lesions protruding into the lumen of the lower third portion of trachea and the main bronchi. AA amyloidosis was confirmed by endobronchial biopsy. Extensive investigations leaded to rule out systemic amyloidosis. Recurrent lower respiratory tract infections marked the outcome of our patient treated by antibiotics.Thirteen years after; the patient was admitted for cough, dyspnea, wheezing. Previous treatment with prednisone and inhaled bronchodilatator had no notable response.Fiberoptic Bronchoscopic examination demonstrated nodular lesions distributed along the cartilaginous rings of lower portion of trachea and the main bronchi. Endobronchial biopsy confirmed the TO.