RT Journal Article
SR Electronic
T1 Lower SNIP value is correlated to the need of intubation in amyotrophic lateral sclerosis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p2099
VO 38
IS Suppl 55
A1 Pierluigi Carratù
A1 Anna Cassano
A1 Giuseppina D'Alba
A1 Vitaliano N. Quaranta
A1 Rosa Capozzo
A1 Felice Gadaleta
A1 Silvano Dragonieri
A1 Isabella L. Simone
A1 Giancarlo Logroscino
A1 Onofrio Resta
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p2099.abstract
AB Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease which usually leads to respiratory failure, requiring Noninvasive Ventilation (NIV) or tracheostomy. No data exist on predictor factors of tracheostomy at the clinical onset of disease.A retrospective study was designed, in a population of 71 consecutive ALS patients (39 males), to evaluate anthropometric, clinical, and functional indicators of the need of tracheostomy, including age, sex, BMI, site of onset, time of diagnosis, co-morbidities, tobacco habit, traumas, sport activity, and sleep disorder breathing markers. Arterial Blood Gas analysis and respiratory functional test, including FVC, FEV1, as well as Sniff Nasal Inspiratory Pressure (SNIP) were also measured at first ambulatory control.We found that SNIP test, at first control, positively correlated to the need of tracheostomy (p<0.001) in the entire population observed. The mean SNIP test value of the group who was admitted to tracheostomy was 25.12 (14.25) compared to a mean SNIP value of 54 (25.46) in the group who did not undergo tracheostomy. Other anthropometric, clinical, functional, and nocturnal parameters evaluated did not correlate to the different outcome in our population of ALS patients.In conclusion, SNIP test could be a useful early indicator of tracheostomy in ALS patients.