TY - JOUR T1 - Volumetric computed tomography screening for lung cancer: three rounds of the NELSON trial JF - European Respiratory Journal JO - Eur Respir J SP - 1659 LP - 1667 DO - 10.1183/09031936.00197712 VL - 42 IS - 6 AU - Nanda Horeweg AU - Carlijn M. van der Aalst AU - Rozemarijn Vliegenthart AU - Yingru Zhao AU - Xueqian Xie AU - Ernst Th. Scholten AU - Willem Mali AU - Erik Thunnissen AU - Carla Weenink AU - Harry J.M. Groen AU - Jan-Willem J. Lammers AU - Kristiaan Nackaerts AU - Joost van Rosmalen AU - Matthijs Oudkerk AU - Harry J. de Koning Y1 - 2013/12/01 UR - http://erj.ersjournals.com/content/42/6/1659.abstract N2 - Several medical associations recommended lung cancer screening by low-dose computed tomography scanning for high-risk groups. Counselling of the candidates on the potential harms and benefits and their lung cancer risk is a prerequisite for screening. In the NELSON trial, screenings are considered positive for (part) solid lung nodules with a volume >500 mm3 and for (part) solid or nonsolid nodules with a volume-doubling time <400 days. For this study, the performance of the NELSON strategy in three screening rounds was evaluated and risk calculations were made for a follow-up period of 5.5 years. 458 (6%) of the 7582 participants screened had a positive screen result and 200 (2.6%) were diagnosed with lung cancer. The positive screenings had a predictive value of 40.6% and only 1.2% of all scan results were false-positive. In a period of 5.5 years, the risk of screen-detected lung cancer strongly depends on the result of the first scan: 1.0% after a negative baseline result, 5.7% after an indeterminate baseline and 48.3% after a positive baseline. The screening strategy yielded few positive and false-positive scans with a reasonable positive predictive value. The 5.5-year lung cancer risk calculations aid clinicians in counselling candidates for lung cancer screening with low-dose computed tomography. 5.5-year lung cancer risk calculations aid clinicians in counselling for lung cancer screening with low-dose CT http://ow.ly/p9J3q ER -