RT Journal Article
SR Electronic
T1 Periodontitis is related to lung volumes and airflow limitation: a cross-sectional study
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1524
OP 1535
DO 10.1183/09031936.00109112
VO 42
IS 6
A1 Birte Holtfreter
A1 Stefanie Richter
A1 Thomas Kocher
A1 Marcus Dörr
A1 Henry Völzke
A1 Till Ittermann
A1 Anne Obst
A1 Christoph Schäper
A1 Ulrich John
A1 Peter Meisel
A1 Anne Grotevendt
A1 Stephan B. Felix
A1 Ralf Ewert
A1 Sven Gläser
YR 2013
UL http://erj.ersjournals.com/content/42/6/1524.abstract
AB This study aimed to assess the potential association of periodontal diseases with lung volumes and airflow limitation in a general adult population. Based on a representative population sample of the Study of Health in Pomerania (SHIP), 1463 subjects aged 25–86 years were included. Periodontal status was assessed by clinical attachment loss (CAL), probing depth and number of missing teeth. Lung function was measured using spirometry, body plethysmography and diffusing capacity of the lung for carbon monoxide. Linear regression models using fractional polynomials were used to assess associations between periodontal disease and lung function. Fibrinogen and high-sensitivity C-reactive protein (hs-CRP) were evaluated as potential intermediate factors. After full adjustment for potential confounders mean CAL was significantly associated with variables of mobile dynamic and static lung volumes, airflow limitation and hyperinflation (p<0.05). Including fibrinogen and hs-CRP did not change coefficients of mean CAL; associations remained statistically significant. Mean CAL was not associated with total lung capacity and diffusing capacity of the lung for carbon monoxide. Associations were confirmed for mean probing depth, extent measures of CAL/probing depth and number of missing teeth. Periodontal disease was significantly associated with reduced lung volumes and airflow limitation in this general adult population sample. Systemic inflammation did not provide a mechanism linking both diseases. Periodontal disease was significantly associated with reduced lung volumes and airflow limitation in an adult population http://ow.ly/oZcsc