RT Journal Article
SR Electronic
T1 Fluticasone propionate decreases MUC5AC expression on airway epithelial cells induced by rhinovirus infection in the airway
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p4095
VO 38
IS Suppl 55
A1 Takenori Okada
A1 Naoto Fueki
A1 Makoto Fueki
A1 Sohei Makino
A1 Hironori Sagara
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p4095.abstract
AB Viral infections such as a common cold in the airway can potentially exacerbate signs and symptom of asthma, including mucus overproduction, airway hyperresponsiveness, and airway obstruction. These signs and symptoms are associated with progression of airway remodeling. MUC5AC is related intimately related to mucus overproduction in the airway and is localized in airway epithelial goblet cells. Fluticasone propionate and salmeterol are used to treat asthma. These drugs prevent exacerbation of asthmatic symptoms due to common colds. However, the effects of these drugs on viral-infected epithelial cells in the airway are unclear.We therefore investigated the effects of fluticasone propionate or salmeterol on rhinovirus 14 (RV14)-induced MUC5AC gene expression in a human airway epithelial cell line (NCI-H292). Fluticasone propionate significantly decreased MUC5AC gene expression in rhinovirus-infected NCI-H292 cells. Our results suggest that fluticasone propionate prevents exacerbation of asthma due to rhinovirus infection by decreasing MUC5AC expression in the airway, potentially slowing the progression of airway remodeling.